EXECUTIVE LEADERSHIP & SCIENTIFIC ADVISORY BOARD
Avologi is a luxurious medical beauty brand founded in 2012 by engineers from the Technion Institute, collaborating with Nobel Prize winner Professor Randy Schekman. Captivating new intelligence in medical beauty solutions and architects of high-tech, Avologi is derived from professional medical and aesthetic treatments, enabling consumers to achieve professional anti-aging results at home.

Randy Schekman, PhD

HHII Professor of Cell and Developmental Biology; 2013 Nobel Laureate in Physiology or Medicine

Yaniv Yuval, BSC

Magna cum laude EE engineering graduate; 2018 Global beauty award winner Technion University

Zvia Hashaiev, RN, BSN, BA, CBC

Plastic surgery and aesthetics specialist Sourasky Medical Center – Ichilov Hospital

Avologi understands the desire for a non-invasive, at-home, easy-to-use, skin care solution. Thus Avologi continues to innovate and create hand held devices that utilize advanced technologies for anyone who wants to take anti-aging into their own hands.

Avologi products offer cutting-edge, proven and dermatologist recommended solutions for skin rejuvenation to address key beauty concerns that consumers encounter. Our advanced products are based on extensive clinical experience, technological innovation and advance knowhow. Offering unique, non-invasive treatments that initialize advanced age defying technologies to help tighten the appearance of sagging skin and reverse the effects of time for a rejuvenated, younger-looking appearance.  

Our mission is to enable consumers to achieve real professional results at the comfort of their own home.

Dr. Randy Schekman is a Professor in the Department of Molecular and Cell Biology, University of California, Berkeley, and an Investigator of the Howard Hughes Medical Institute.  He studied the enzymology of DNA replication as a graduate student with Arthur Kornberg at Stanford University.  His current interest in cellular membranes developed during a postdoctoral period with S. J. Singer at the University of California, San Diego.  Schekman’s laboratory investigates the mechanism of membrane protein traffic in the secretory pathway in eukaryotic cells. In recent years his lab has turned to aspects of vesicular traffic in human cells, most recently on the biogenesis and sorting of small RNAs into extracellular vesicles.

Among his awards are the Gairdner International Award, the Albert Lasker Award in Basic Medical Research and the Nobel Prize in Physiology or Medicine, which he shared with James Rothman and Thomas Südhof.  From 2006 – 2011 he served as Editor-in-Chief of the Proceedings of the NAS.  In 2011, he founded and until 2019 served as the Editor-in-Chief of the Open Access journal, eLife, sponsored by the HHMI, Wellcome Trust and the Max Planck Society.  Beginning in 2018, Schekman assumed a leadership role in an effort supported by the Sergey Brin Family Foundation to identify and support basic research on the mechanisms of Parkinson’s Disease initiation and progression (https://parkinsonsroadmap.org). 

Human cells manufacture over 20,000 different proteins which consist of amino acids stitched together to create the many molecules that catalyze and organize cellular processes.  Most of these proteins are designed to function within the cell but a significant fraction of them, molecules such as insulin, growth factors and collagen are shipped out by a process called secretion.

This process was poorly understood at the molecular level until work in Schekman lab, using a simple genetic approach with Baker’s yeast, and a biochemical approach using cultured mammalian cells, pioneered in Jim Rothman’s lab, led to the isolation of the genes and proteins that organize the secretory pathway. 

A sequence comparison of the genes required for secretion in yeast and the genes that encode proteins required for membrane traffic in mammalian cells showed that the process is conserved over 2B years of evolution.  Given this functional conservation, the biotechnology industry exploited yeast as a platform for the production of large quantities of medically important proteins such as recombinant human insulin and the protein used in hepatitis B vaccination.  For this work, Schekman and Rothman (along with Thomas Sudhof) shared the 2013 Nobel Prize in Physiology/Medicine.

More recent work has demonstrated that many cells also secrete small membrane carriers called extracellular vesicles (EVs) or exosomes.  EVs may carry proteins and RNA to target cells to change the pattern of gene expression or in disease, to promote some pathological process.  The Schekman lab now studies EVs assembly, RNA packaging and the effect of isolated EVs on target cell growth and differentiation.  In one such study, the lab has found EVs isolated from skin cells (fibroblasts of keratinocytes) stimulate the migration of cells in a wound healing assay.

The hope is that by understanding this process, the vesicles may be used to deliver therapeutic molecules to cells or tissues in humans, e.g. in skin wound healing.

Review by Dr. Stefano Magno

Dr Magno Stefano - skin surgeon.

Practicing medicine for more than 25 years

Totale is a really powerful facial treatment, I really believe that this device is revolutionary in terms of facial treatments.

Dr Magno Stefano

Graduated in Medicine at Catholic University of Rome in 1998, presenting the paper: “Sentinel lymph node biopsy in breast cancer”.

Specialty in general surgery achieved in 2005, presenting the work “Excision margin status and local recurrence in the conservative treatment of breast cancer”.

Since 1995, clinical practice in General Surgery first as student and then as a resident; from 2005 on, surgeon in the Breast Surgery Unit of Catholic University of Rome, particularly focused in clinical and scientific aspects of oncology.
He has performed more than 1.100 surgical interventions (680 as first operator); among them, over 350 breast procedures.

From 1999 to 2006 collaboration with Italian Soccer Federation as physician of National team in the categories under 20 of age

Since 2000, member of the Italian affiliate of a prestigious American non-profit Organization (“Susan G. Komen for the Cure”), focused on breast cancer prevention and treatment.

In february 2002, visiting Resident in the Breast center of “Memorial Sloan Kettering Cancer Center” – New York.

From 2005 to 2008, collaboration with a prestigious scientific Institution (Merck Biochemicals) on the project “Identification of therapeutic targets expressed on breast cancer stem cells”

Completed a three-year universitary course on acupuncture 

Member of the Organizing Committee of several International and National Scientific Symposiums 

Since 2000, collaboration as teaching professor in a National Educational Program on Breast cancer prevention in Italy, granted by non-profit associations and Italian Government. 

Publications:           

Crucitti A., La Greca A., Antinori A., Pirulli P., Consiglio F., Magno S., Antonacci V., Masetti R.

“Pancreaticoduodenectomy for pancreatic and periampullary tumors : technical considerations and results” ; “Journal of Surgical Oncology” – Aprile 1999

Masetti R., Antinori A., Pirulli P., Magno S.

Chapter “Mappaggio linfonodale intraoperatorio e biopsia del linfonodo sentinella “  – Bonifacino – Buzdar – Halliwell ; Poletto Editore – 1999.

Masetti R., Antinori A., Pirulli P., Magno S., Zazza S.

Chapter “Chirurgia oncoplastica : radicalità oncologica e cosmesi”  – Ottobre 1999 ; Edizioni Idelson-Gnocchi.

R. Masetti, A. Antinori, P.G. Pirulli, S. Magno, F. Chiesa 

“Oncoplastic techniques in the conservative surgical treatment of breast cancer”.

 Breast Cancer 2000, 7 (4): 276-280.

R. Masetti, G. Franceschini, S. Magno, F. Chiesa 

Chapter “La chirurgia oncoplastica della mammella”; Ediz. CLUB -U.E.C. (Pavia): 156-188, 2001

R. Masetti, G. Franceschini, S. Magno, F. Chiesa, R. Pigalarga.

Chapter “DCIS: il chirurgo”- Bari, 121-126; 2002

R.Masetti, G.Franceschini, F.Chiesa, S.Magno, A.Di Leone.

“Oncoplastic surgical techniques in the treatment of breast cancer”. Istanbul Kanser Konferansi Ozet Kitabi. Meme Hast. Derg. 2003; 10(3): 64.

A.Di Leone, S.Magno, F.Chiesa, M.Fabbri, R.Masetti.

“L’intervento chirurgico e l’approccio interdisciplinare nella terapia della neoplasia mammaria”

Atti dell’Accademia Lancisiana, Dicembre 2004

R.Masetti, S.Magno, F.Chiesa, A.Di Leone

“Oncoplastic approaches in the surgical treatment of breast cancer”.

Selected paper (Abstract) – 3th Congress of the World Society for breast health, Aprile 2005

R.Masetti, S.Magno, F.Chiesa, A.Di Leone

“Management of breast cancer in elderly”.

Abstract – 10th Annual Multidisciplinary Symposium on breast disease, Luglio 2005

R.Masetti, A.Di Leone, G.Franceschini, S.Magno, D.Terribile, Maria Cristina Fabbri and F.Chiesa.

“Oncoplastic techniques in the conservative surgical treatment of breast cancer: an overview”.

The Breast Journal 2006, 12 (2): 174-180.

G.Franceschini, D.Terribile, S.Magno, C. Fabbri, P.D’Alba, F.Chiesa, A.Di Leone, R.Masetti.

“Ductal carcinoma in situ. Surgical therapy: a mini review”.

Chirurgia 2007, 20 : 1-3.

G.Franceschini, D.Terribile, C. Fabbri, S.Magno, P.D’Alba, F.Chiesa, A.Di Leone, R.Masetti.

“Management of locally advanced breast cancer”.

Minerva Chirurgica 2007, 62 : 249-255.

G.Franceschini, D.Terribile, S.Magno, C. Fabbri, P.D’Alba, F.Chiesa, A.Di Leone, R.Masetti.

“Update in the treatment of locally advanced breast cancer: a multidisciplinary approach”.

Eur Rev Med Pharmacol Sci 2007, 11(5) : 283-289.

G.Franceschini, D.Terribile, C.Fabbri, S.Magno, P.D’Alba, F.Chiesa, A.Di Leone, R.Masetti.

“Evoluzione nel trattamento chirurgico del carcinoma mammario precoce”.

Annali Italiani di Chirurgia 2008, 79 : 17-22.

G.Franceschini, D.Terribile, S.Magno, C.Fabbri, P.D’Alba, F.Chiesa, A.Di Leone, R.Masetti.

“Conservative treatment of the central breast cancer with nipple-areolar resection: an alternative oncoplastic technique”.

G.Chir 2008, 29 : 23-27.

G.Franceschini, D.Terribile, S.Magno, C.Fabbri, P.D’Alba, F.Chiesa, A.Di Leone, R.Masetti.

“Current controversies in the treatment of ductal carcinoma in situ of the breast”.

Annali Italiani di Chirurgia 2008, 79 .

S.Magno

Chapter: “Le cellule staminali nel carcinoma della mammella” dal libro “Seno buono, seno cattivo”– Edizioni Alpes – Roma, novembre 2008

S.Magno, D.Terribile, G.Franceschini, C.Fabbri, P.D’Alba, F.Chiesa, A.Di Leone, M.Costantini, P.Belli and R.Masetti.

“Breast MRI in a case of “early onset” lactating adenoma”.

The Breast Journal 2009, 15(1): 105-106.

S.Magno, D.Terribile, G.Franceschini, C.Fabbri, P.D’Alba, F.Chiesa, A.Di Leone and R.Masetti.

“Accessory nipple reconstrunction following a central quadrantectomy: a case report”.

Cases Journal 2009, 2 (32).

S.Magno, D.Terribile, G.Franceschini, C.Fabbri, P.D’Alba, F.Chiesa, A.Di Leone, M.Costantini, P.Belli and R.Masetti.

“Early onset lactating adenoma and the role of breast MRI: a case report”.

Journal of Medical Case Reports 2009, 3(43).

G.Franceschini, D.Terribile, I. Scafetta, S.Magno, C.Fabbri, F.Chiesa, A.Di Leone, F.Moschella, A. Mulè and R.Masetti.

“Conservative treatment of a rare case of  a multifocale adenoid cystic carcinoma of the breast: case report and literature review”.

Med Sci Monit  2010, 16(3) CS 33-39.

P. Rinaldi, M. Giuliani, P.Belli, M.Costantini, M. Romani, D.Di Stefano, E. Bufi, A.Mulè, S.Magno, R.Masetti and L. Bonomo

“DWI in breast MRI: role of ADC value to determine diagnosis between diagnosis and surgical scar in operated patients”.

Eur J Radiol 2010, 19 Feb

Rinaldi P, Ierardi C, Costantini M, Magno S, Giuliani M, Belli P, Bonomo L.

“Cystic breast lesions: sonographic findings and clinical management”.

Ultrasound Med. 2010, Nov;29(11):1617-26. 

Magno S, Nanni L, Retrosi G, Cina A, Gamba PG.

“An Unusual Case of acute Pancreatitis and Gastric Outlet Obstruction Associated with Wandering Spleen Treated by Laparoscopic Splenopexy”.

Laparoendosc Adv Surg Tech 2011, Mar 5.

ABOUT AVOLOGI

Avologi is a luxurious medical beauty brand founded in 2012 by engineers from the Technion Institute. Captivating new intelligence in medical beauty solutions and architects of high-tech, Avologi is derived from professional medical and aesthetic treatments, enabling consumers to achieve professional results at home.

Avologi understands the desire for a non-invasive, at-home, easy-to-use, anti-aging solution, Thus Avologi continues to innovate and create handheld device that utilize advanced technologies for anyone who wants to take anti-aging into their own hands.

The Avologi products offer cutting-edge,  proven and dermatologist recommended solutions for skin rejuvenation to address key beauty concerns that customers encounter.

Our mission is to enable consumers to achieve real professional Anti-Aging results at the comfort of their own home.

About Eneo

Our best-selling product- ENEO advanced – A revolutionary, professional, FDA cleared class II anti-aging medical device that provides immediate improvements with long lasting results on face & body. This noninvasive, clinically tested, dermatologist recommended medical device, dramatically changes the way anti-aging treatments have been performed for the past 15 years.

Fine lines, wrinkles, pigmentation, enlarged pore size and discoloration, can now be targeted immediately.
ENEO advanced uses dual wavelengths of 633 and 830 nanometers with precise penetration to the dermis, enhancing the anti-aging treatment by use of micro pulse therapy, 24 karat gold applicator tip and detox blue light.

These combined technologies ensure sustainable skin rejuvenation results with minimum effort, zero side effects and no allergies.

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